Click Save to open the Manage Variables dialog.
It shows all changes you have just made. The old and the new value are displayed so that you can check your changes again.
New values are only applied after a service restart.
If the variable is already in use, you have the option of restarting all - or selected - services directly.
Select the services you want to restart in the displayed list.
Click Save to save your changes and restart the selected services.